- #Rigs of rods mods hemibody software#
- #Rigs of rods mods hemibody simulator#
- #Rigs of rods mods hemibody free#
In the p53-/- animals, brain MF increased to 2.2-fold above spontaneous levels at 1 week after treatment, but returned to control levels thereafter. In contrast, brain MF from the same animals increased 1.7-fold above controls in the same period. MF in the spleen of p53+/+ animals increased up to 2.6-fold above spontaneous levels at 8 weeks post irradiation. We measured lacZ mutation frequencies (MF) in the brain and spleen tissues at various times after exposing animals to an acute dose of 1 Gy of 1GeV/amu iron particles. We are using the plasmid-based lacZ transgenic mice with different p53 genetic background to examine radiation-induced genetic damage resulting from exposure to heavy particle radiation. Transgenic animals, with the integrated target gene, provide a unique approach for measuring and characterizing mutations in any tissue of the animal. HZE particle radiation induces tissue-specific and p53-dependent mutagenesis in transgenic animalsĬhang, P. Further understanding the molecular signaling pathways of cytokines and chemokines would reveal novel targets for protecting or mitigating radiation injury of tissues and organs.
Better understanding the mechanisms mediating interactions among excessive generation of reactive oxygen species, production of pro-inflammatory cytokines and activated macrophages, and role of bone marrow-derived progenitor and stem cells may provide novel insight on the pathogenesis of radiation-induced injury of tissues.
#Rigs of rods mods hemibody free#
Emerging concepts of radiation-induced normal tissue toxicity suggest that the recovery and repopulation of stromal stem cells remain chronically impaired by long-lived free radicals, reactive oxygen species, and pro-inflammatory cytokines/chemokines resulting in progressive damage after radiation exposure. The principal pathogenesis is initiated by depletion of tissue stem cells and progenitor cells and damage to vascular endothelial microvessels. Injury to critical normal tissues and organs, however, poses substantial risks in the curative treatment of cancers, especially when radiation is administered in combination with chemotherapy. Advances in radiation delivery using megavoltage and intensity-modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor target tissues.
To summarize current knowledge regarding mechanisms of radiation-induced normal tissue injury and medical countermeasures available to reduce its severity. It is a very clever piece of software.Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials
#Rigs of rods mods hemibody software#
When you crash a car into a wall, it may look like a crash to you, but the software calculates what would crumple first, what would bend, crack, smash, and how the impact, pressure and vibrations would affect the rest of the car. The way a boat sits in the water is calculated. This game is similar because even though the concept appears simple, there is a massive amount of mathematics and engineering skill that has gone into it.Įven the way a plane flies is calculated based on air pressure, resistance, the plane dimensions, the pressure within the engines, and much more.
#Rigs of rods mods hemibody simulator#
The simulator could be compared to a car, because on the surface, a car looks like a tin box, but on the inside, there is millions of pounds worth of research and engineering. For example, if you derail a train, you get to see what would happen, for example, which carts would fly off and where. When you crash something, you get to see how it would act and react in real life. You can do mostly whatever you want to do on the maps, and there are plenty of vehicles to choose from. There is no real point to the game, but crashing is a fun part of it. It also means that things such as crashes and such will appear more real and genuine. This means the vehicles in the game will act and react a little more realistically than in most games and simulators. It is more of a vehicle simulator with soft body physics. For this reason, the software may be good for programmers, and there is a fairly large community of people that add things to the software every now and again. It also means you can take the coding, add to it, and change it if you wish. It is open source, which means you can see the coding that was used to create the program.
Yet, the software has had so much effort, time and resources put into it that it seems a shame there is not a bigger market for this sort of thing. Rigs of Rods is a strange and unusual piece of software because it doesn’t seem to have a point if you are not part of the vehicle-manufacturing scene. An open source vehicle simulator with soft-body physics.
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